Immunoelectron cytochemical localization of motilin in human duodenal enterochromaffin cells.

作者: Philipp U. Heitz , Marlis Kasper , Gunthild Krey , Julia M. Polak , A.G.E. Pearse

DOI: 10.1016/0016-5085(78)90249-4

关键词: Internal medicinePeptideMotilinMolecular biologyEndocrinologyJejunumImmunoelectron microscopyDuodenumBiogenic amineCellChemistryEnterochromaffin cell

摘要: Abstract Two types of enterochromaffin cells can be demonstrated in the human duodenal mucosa by means Masson-Fontana reaction for argentaffinity applied to ultrathin sections. The 22-amino acid peptide motilin has now been localized exclusively type cell immunoelectron microscopy. This occurs predominantly duodenum and upper jejunum. It is concluded that at least two exist gut they produce one biogenic amine as well peptides. Therefore could provide a useful model studies interrelationship storage release amines

参考文章(30)
A. G. E. Pearse, Peptides in brain and intestine Nature. ,vol. 262, pp. 92- 94 ,(1976) , 10.1038/262092A0
P. Mitznegg, S.R. Bloom, W. Domschke, S. Domschke, E. Wuensch, L. Demling, Pharmacokinetics of Motilin in Man Gastroenterology. ,vol. 72, pp. 413- 416 ,(1977) , 10.1016/S0016-5085(77)80249-7
DAVID POWELL, SUSAN LEEMAN, GEOFFREY W. TREGEAR, HUGH D. NIALL, JOHN T. POTTS, Radioimmunoassay for substance P. Nature. ,vol. 241, pp. 252- 254 ,(1973) , 10.1038/NEWBIO241252A0
R. H�kanson, Ch. Owman, N. O. Sj�berg, B. Sporrong, Amine mechanisms in enterochromaffin and enterochromaffin-like cells of gastric mucosa in various mammals. Histochemistry and Cell Biology. ,vol. 21, pp. 189- 220 ,(1970) , 10.1007/BF00304213
R D Lillie, THE INDOLE REACTIONS OF "ENTERAMINE" AND ENTEROCHROMAFFIN: A HISTORICAL SURVEY Journal of Histochemistry and Cytochemistry. ,vol. 25, pp. 27- 31 ,(1977) , 10.1177/25.1.401845
ENRICO SOLCIA, ROBERTO BUFFA, AZO COUPLING OF INDOLE-REACTIVE ENTEROCHROMAFFIN CELLS Journal of Histochemistry and Cytochemistry. ,vol. 22, pp. 127- 127 ,(1974) , 10.1177/22.2.127
N. T. RAIKHLIN, I. M. KVETNOY, V. N. TOLKACHEV, Melatonin may be synthesised in enterochromaffin cells. Nature. ,vol. 255, pp. 344- 345 ,(1975) , 10.1038/255344A0
G. Nilsson, L.-I. Larsson, R. H�kanson, E. Brodin, B. Pernow, F. Sundler, Localization of substance P-like immunoreactivity in mouse gut. Histochemistry and Cell Biology. ,vol. 43, pp. 97- 99 ,(1975) , 10.1007/BF00490158
A. G. E. Pearse, Julia M. Polak, S. R. Bloom, Caroline Adams, Jill R. Dryburgh, J. C. Brown, Enterochromaffin cells of the mammalian small intestine as the source of motilin Virchows Archiv B Cell Pathology. ,vol. 16, pp. 111- 120 ,(1974) , 10.1007/BF02894069