Brain ethanol in AA, ANA, and Wistar rats monitored with one-minute microdialysis
作者： Maria Nurmi , Kalervo Kiianmaa , John David Sinclair
DOI: 10.1016/0741-8329(94)90098-1
关键词: Metabolism 、 Endocrinology 、 Nucleus accumbens 、 Internal medicine 、 Alcohol 、 Ethanol 、 Rat brain 、 Chemistry 、 Ethanol metabolism 、 Anesthesia 、 Toxicokinetics 、 Microdialysis
摘要: A microdialysis system for measuring the ethanol concentration curve in nucleus accumbens of rat brain was developed and tested three different lines (AA, ANA, Wistar) after an intraperitoneal (IP) intragastric (IG) dose 1.0 g/kg ethanol. The flow rate modified Ringer solution set at 5 microliters/min; samples were taken every minute administration analyzed with headspace gas chromatography. After IP administration, levels rose much more rapidly than tail blood same animals. maximum level IG lower occurred later, similar to AA ANA rats. No clear difference between found but there some indication that rats may absorb alcohol intubation faster or Wistar
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