Distribution of transforming growth factor-β1 in human astrocytomas
作者： Heinz-A. Horst , Bernd W. Scheithauer , Patrick J. Kelly , John S. Kovach
DOI: 10.1016/0046-8177(92)90297-G
关键词: Cytokine 、 Immunohistochemistry 、 Tumor-infiltrating lymphocytes 、 Antibody 、 Staining 、 Astrocytoma 、 Biology 、 Lymphocyte 、 Pathology 、 Tumor Infiltrating Macrophages
摘要: Abstract We used immunohistochemical techniques to study the distribution of transforming growth factor-β 1 (TGF-β ) and infiltrating lymphocytes macrophages in human astrocytomas. Thirteen 15 grade 4 astrocytomas (glioblastomas) showed staining with anti-TGF-β antibody, predominantly proliferating endothelial complexes surrounding small medium-sized blood vessels. Brain tissue microscopically free tumor cells (n = 8) more differentiated varying (1 3; n=6) devoid proliferation did not stain . Normal brain contained only rare lymphoreticular cells. The majority studied, however, T smaller numbers B lymphocytes. infiltrates were concentrated primarily close proximity Within an individual perivascular regions for TGF-β never than occasional Perivascular frequently low high inverse relationship lymphocyte is compatible a functional between this cytokine immune effector cell response glioblastomas.
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