Signals mediating nuclear targeting and their regulation: Application in drug delivery

摘要: The recent progress with respect to understanding the signals mediating transport of proteins in both directions through NPC, and cellular interacting these effect process has made possible a number advances terms use this information clinical setting. In particular, our knowledge mechanism regulation process, how we may exploit machinery itself therapeutic situation, especially where there be pathways specific particular viruses, advanced considerably. context, review expounds current conferring targeting nucleus, their practical potential delivering molecules interest nucleus context. It also deals nuclear protein export/shuttling between cytoplasmic compartments as well those or retention, mechanisms regulating activity signals, signal-dependent import. Detailed processes signal-mediated import/export its enables considered application optimization approaches target interest, such plasmid DNA toxic molecules, efficiently according need research enhance expression efficiency action, respectively. context is reviewed, future possibilities growing are discussed. © 1998 John Wiley & Sons, Inc. Med. Res. Rev., 18, No. 4, 189–223, 1998.