Association Between Osteoprotegerin G1181C and T245G Polymorphisms and Diabetic Charcot Neuroarthropathy A case-control study

摘要: OBJECTIVE Charcot neuroarthropathy is a disabling complication of diabetes. Although its pathogenesis remains unknown, we suppose that genetics may play relevant role. RESEARCH DESIGN AND METHODS We performed case-control study with 59 subjects diabetic (Ch group), 41 neuropathy without (ND and 103 healthy control (H group) to evaluate the impact two single nucleotide polymorphisms (SNPs) osteoprotegerin gene (G1181C T245G) on risk neuroarthropathy. RESULTS Regarding SNPs G1181C, found significant linkage between G allele vs. ND, odds ratio [OR] 2.32 [95% CI 1.3–4.1], P = 0.006; Ch H, 2.10 [1.3–3.3], 0.002; ND 0.90 [0.7–1.9], 0.452); similarly, T245G 6.25 [2.2–19.7], < 0.001; 3.56 [1.9–6.7], 0.54 [0.6–5.7], 0.304), supporting protective role for C T, respectively. For this reason investigated frequency double homozygosis CC + TT (7% in Ch) was significantly lower compared H (0.18 [0.06–0.5], 0.002) (0.17 [0.05–0.58], 0.006), whereas there no difference (1.05 [0.43–2.0], 0.468). In multivariate logistic backward regression model, only weight lack genotypes were independently associated presence neuroarthropathy. CONCLUSIONS This first shows an association genetic regulation bone remodeling neuroarthropathy.