Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration.

摘要: Regular physical exercise is the most efficient and accessible intervention known to promote healthy aging in humans. The molecular cellular mechanisms that mediate system-wide benefits, however, remain poorly understood, especially as applies tissues do not participate directly training activity. establishment of protocols for short-lived genetic models will be critical deciphering fundamental transtissue benefits aging. Here we document optimization a long-term swim protocol Caenorhabditis elegans demonstrate its diverse tissues, even if occurs only during restricted phase adulthood. We found multiple daily sessions are essential adaptation, leading body wall muscle improvements structural gene expression, locomotory performance, mitochondrial morphology. Swim enhances whole-animal health parameters, such respiration midlife survival, increases functional healthspan pharynx intestine, nervous system by increasing learning ability protecting against neurodegeneration tauopathy, Alzheimer’s disease, Huntington’s disease. Remarkably, early adulthood induces long-lasting systemic several cases still detectable well into midlife. Our data reveal broad impact promoting extended C. underscore potency experience influence health, establish foundation exploiting powerful advantages this model dissection exercise-dependent circuitry confers adults.