Effect of combination antiretroviral therapy upon rectal mucosal HIV RNA burden and mononuclear cell apoptosis.
作者： Donald P. Kotler , Terumasa Shimada , Gail Snow , Glenda Winson , Wei Chen
DOI: 10.1097/00002030-199806000-00008
关键词: Immunology 、 Peripheral blood mononuclear cell 、 Lamina propria 、 Viral load 、 Immunopathology 、 Viral disease 、 Lymphocyte 、 Lentivirus 、 Virus 、 Medicine
摘要: Background: Pathogen-negative diarrhea is common in HIV infection and has been associated with clinical symptoms, histopathology, expression, CD4+ lymphocyte depletion, cytokine mRNA apoptosis of lamina propria mononuclear cells. Objectives methods: To examine the short-term (7-day) effects treatment combination antiretroviral therapies upon gastrointestinal symptoms rectal mucosa 15 HIV-infected subjects. Results: Treatment was significant decreases perception abdominal bloating cramps. Similar declines RNA burden rises counts were found blood mucosa. also a fall number cells undergoing by situ labeling, change that correlated mucosal viral burden. Conclusions: Peripheral compartments are equally responsive to effective therapies. The detection changes within 7 days starting antiviral therapy implies intestinal dysfunction may be direct result local infection.
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