Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells.
作者： U H Kim , D Fink , H S Kim , D J Park , M L Contreras
DOI: 10.1016/S0021-9258(18)52299-7
关键词: Phosphorylation 、 Biology 、 Phospholipase C 、 Protein phosphorylation 、 Serine 、 Nerve growth factor 、 Phospholipase C gamma 、 Cell culture 、 Molecular biology 、 Tyrosine
摘要: PC12 cells contain at least three immunologically distinct phospholipase C (PLC) isozymes, PLC-beta, PLC-gamma, and PLC-delta. Treatment of with nerve growth factor (NGF) leads to an increase in the phosphorylation but not PLC-beta or This can be seen as little 1 minute. The increased occurs on both serine tyrosine residues, major being former. result suggests possibility that NGF-dependent phosphoinositide hydrolysis is due selective PLC-gamma by protein kinases associated NGF receptor.
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