Postmortem distribution of mexiletine in a fatal overdose.
作者： Timothy P. Rohrig , Linda E. Harty
DOI: 10.1093/JAT/18.6.354
关键词: Mexiletine 、 Toxicokinetics 、 Anesthesia 、 Drug intoxication 、 Distribution (pharmacology) 、 Quantitative analysis (chemistry) 、 Tissue distribution 、 Toxicity 、 Biological materials 、 Medicine
摘要: A case involving a fatal overdose of mexiletine is presented. Quantitation the drug was accomplished by gas chromatography with flame-ionization detector. The presence confirmed chromatography-mass spectrometry. Toxicological analysis revealed following tissue distribution mexiletine: heart blood, 44.8 micrograms/mL; femoral 10.0 vitreous, 8.6 liver, 171.6 micrograms/g; brain, 84.0 and gastric contents, 1464 mg.
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