Histiocytosis With Raisinoid Nuclei: A Unifying Concept for Lesions Reported Under Different Names as Nodular Mesothelial/Histiocytic Hyperplasia, Mesothelial/Monocytic Incidental Cardiac Excrescences, Intralymphatic Histiocytosis, and Others: A Report of 50 Cases.

摘要: We report 50 cases of peculiar histiocytic proliferations occurring in diverse body sites that currently bear various names, including nodular mesothelial/histiocytic hyperplasia, aggregates, mesothelial/monocytic incidental cardiac excrescences, reactive eosinophilic pleuritis, histioeosinophilic granuloma the thymus, and intralymphatic histiocytosis. They can sometimes cause considerable differential diagnostic difficulties by resembling a metastatic carcinoma or Langerhans cell Several previous publications have established link between some these conditions, suggesting are merely variations within histopathologic spectrum, affecting different organs bearing names based on particular location. However, no publication has ever comprehensively addressed all lesions together one study an attempt to explain discuss their striking analogy. Having studied large series we provide evidence share same morphologic, immunohistochemical, pathogenetic properties, thus they represent pathologic process should be referred as such. Taking into account typical nuclear features propose collective term "histiocytosis with raisinoid nuclei" for this spectrum conditions.