Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus.
作者： N Xu , J Dong , Y Yang , X Ai
DOI: 10.3354/DAO02979
关键词: Animal science 、 Absorption (skin) 、 Praziquantel 、 Biology 、 Oral administration 、 Half-life 、 Monopterus 、 Residue (complex analysis) 、 Pharmacology 、 Bioavailability 、 Pharmacokinetics
摘要: We investigated the pharmacokinetic characteristics of praziquantel (PZQ) in rice field eels Monopterus albus. Pharmacokinetic parameters were determined following a single intravenous administration (5 mg kg(-1) body weight [bw]) and oral (10 bw) at 22.0 ± 0.7°C. also evaluated residue depletion tissues daily PZQ that was given orally for 3 consecutive days Following treatment, plasma concentration-time curve best described by 3-compartment open model, with distribution half-life (t(1/2α)), elimination (t(1/2β)), area under (AUC) 0.54 h, 17.10 14505.12 h µg l(-1), respectively. After administration, 1-compartment model first-order absorption, absorption (t(1/2Ka)), (t(1/2Ke)), peak concentration (C(max)), time-to-peak (T(max)), AUC estimated to be 2.28 6.66 361.29 5.36 6065.46 The bioavailability (F) 20.9%. With respect PZQ, t(1/2β) values muscle, skin, liver, kidney 20.2, 28.4, 14.9, 54.1 Our results indicated rapid elimination, low tested dosing conditions.
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