Comparison of praziquantel pharmacokinetics and tissue distribution in fresh and brackish water cultured grass carp ( ctenopharyngodon idellus ) after oral administration of single bolus

摘要: Praziquantel (PZQ) is an effective pesticide against monogeneans. Its pharmacokinetics in fish may be affected by water environment and temperature. The present study was designed to compare the pharmacokinetics, tissue distribution, elimination of PZQ freshwater-acclimated grass carp brackish cultured carp. Plasma concentrations were determined after a single 10 mg/kg oral dose. datas plasma tissues drug concentration calculated software SPSS 13.0. According One-Way ANOVA, results showed that salinity had significant effect on (p < 0.01), muscle liver (p < 0.01) kidney all sampling time points between carps freshwater carps, wherein, group constantly lower than group. peak levels plasma, muscle, liver, kidneys 0.76 μg/ml, 0.51 μg/g, 2.7 μg/g, 2.99 μg/g, respectively; 0.91 μg/ml, 0.62 μg/g, 3.87 μg/g, 3.39 μg/g, respectively. half-lives (t1/2β) significantly longer 56.46, 36.17, 15.31, 132.64 h, 71.15, 44.88, 23.86, 150.23 h, These findings indicate affects distribution more rapid fresh are orally administrating same dosage at We speculate main excretion pathway through renal elimination, decreased function likely responsible for considerable difference two groups carps.