Comparative pharmacokinetics and bioavailability of oxytetracycline in rainbow trout and chinook salmon.

摘要: Abstract The pharmacokinetics and bioavailabilities of oxytetracycline (OTC) in seawater chinook salmon ( Oncorhynchus tshawytscha ) freshwater rainbow trout mykiss were compared after they given a single dose OTC (50 mg/kg) via the i.a. or per os route administration at 11°C water. At specific time points post-dosing, blood samples withdrawn from fish, extracted by solid phase extractor analyzed for with high performance liquid chromatograph (HPLC). Similar concentration–time profiles found treated same OTC. A two- three-compartment open pharmacokinetic models, respectively, used to describe following routes administration. model-derived parameters apparent also remarkably similar: elimination half-life, volume distribution oral bioavailability 88.29 h, 0.89 l/kg 24.84%, respectively; corresponding values 94.22 0.87 30.30%, respectively. Results present studies indicate that species difference salinity as 24‰ do not play an important role absorption salmonids. Moreover, may be model salmonid study vice versa.