Bioavailability and pharmacokinetics of a praziquantel bolus in kingfish Seriola lalandi.

摘要: Oral praziquantel (PZQ) preparations have recently been investigated for the treatment of monogeneans that infect skin and gills kingfish Seriola lalandi cultured in sea-cages. To evaluate an oral PZQ dosing strategy, pharmacokinetics a dissolved feed preparation (40 mg kg(-1) body weight) were compared with intravenous bolus plasma using HPLC. Compared administration, bioavailability (area under curve, AUC0-24h) was slightly improved when drug administered food both (56.8% vs. 50.8% solution) (55.5% 50.3% solution). After dosing, maximum concentrations approximately one-third those achieved higher solution (5.26 microg ml(-1)) than (3.96 ml(-1)); additionally, time to achieve concentration similar skin, although markedly reduced (1 h) (6 h). However, clearance delayed skin; as formulation, systemic circulation fell below limit quantification after 24 h, but remained quantifiable (0.3 g(-1)) at this time. These initial studies indicate daily interval will lead exposure parasites highly variable anthelmintic concentrations, which may be sub-optimal finfish species.