The uterus sustains stable biological clock during pregnancy.
作者： Shizuko Akiyama , Hidenobu Ohta , Shimpei Watanabe , Takahiro Moriya , Aya Hariu
DOI: 10.1620/TJEM.221.287
关键词: Circadian rhythm 、 PER1 、 Uterus 、 Pregnancy 、 Fetus 、 Placenta 、 Endocrinology 、 Decidua 、 Internal medicine 、 Biology 、 CLOCK
摘要: Maternal circadian information has been reported to play an important role in fetal physiology and development. Hormones nutrition have mainly investigated as cues from mother fetus. However, the influences of properties pregnant reproductive organs on fetuses not fully investigated. To gain insight functions organs, we examined molecular clocks rat uterus placenta. By using a Period1-luciferase (Per1-luc) rat, whose tissues express luciferase corresponding activation Period1, "key clock gene", during non-pregnancy, embryonic day 12 (E12), E22 (the end pregnancy) light-dark (LD) cycle constant darkness (DD). situ hybridization further explored Per1 mRNA rhythms placenta E12 E22. The vitro showed clear Per1-luc both out pregnancy, having peaks at around time dusk LD. Likewise, DD, had same rhythms. decidua LD rhythms, peaking night 6 h after dusk, while DD only In contrast, labyrinth no or pregnancy. These results suggest that decidua, maternally-originated tissue placenta, but labyrinth, fetus-originated can provide fetus with information.
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