Role of phytochemicals in the inhibition of epithelial–mesenchymal transition in cancer metastasis

作者: Eun-Kyung Kim , Eun-Ju Choi , Trishna Debnath

DOI: 10.1039/C6FO00901H

关键词: Cancer researchResveratrolCancer metastasisBiologySignalling pathwaysImmunologyMotilityMesenchymal stem cellCancer cellEpithelial–mesenchymal transitionSignal transduction

摘要: Epithelial–mesenchymal transition (EMT) is the process by which epithelial cells become mesenchymal cells, gaining fibroblast-like properties and displaying reduced intercellular adhesion increased motility. EMT plays an important role in cancer metastasis. Suppressing or reversing therefore way of controlling various cancers. Phytochemicals are sources anticancer lead molecules. Natural products have been shown to safely suppress reverse via inhibition associated signalling pathways cells. In present review, we discuss relevant factors We then examples phytochemicals with a reversal cancers, focusing on reports from 2012 2016.

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