DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights
作者： Soledad Gómez , Giancarlo Castellano , Gemma Mayol , Mariona Suñol , Ana Queiros
DOI: 10.1016/J.GDATA.2015.07.016
关键词: Biology 、 Control parameters 、 Microarray analysis techniques 、 Methylation 、 DNA microarray 、 Neuroblastoma 、 Genetics 、 DNA methylation 、 Epigenetics 、 Tumor biology
摘要: Neuroblastoma (NB) is one of the most frequently occurring extracranial solid tumors childhood (Maris et al., 2007 [1]; Brodeur, 2003 [2]). Probability cure varies according to patient's age, extent disease and tumor biology [2]; Cohn 2009 [3]). However, etiology this developmental unknown. Recent evidence has shown that pediatric tumors, including NB, harbor a paucity recurrent genetic mutations, with significant proportion events converging on epigenetic mechanisms (Cheung 2012 [4]; Molenaar [5]; Pugh 2013 [6]; Sausen [7]. We have analyzed DNA methylome neuroblastoma using high-density microarrays (Infinium Human Methylation 450k BeadChip) define landscape its potential clinicopathological impact. Here, we provide detail methods quality control parameters microarray data used for study. been deposited at NCBI Gene Expression Omnibus repository, accession number GSE54719; superseries record GSE54721.
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