HRF-Interacting Molecules
作者： Toshiaki Kawakami , Tomoaki Ando , Yuko Kawakami
DOI: 10.2174/1874838401205010041
关键词: Secretory pathway 、 Cell 、 Intracellular 、 Extracellular 、 Translationally-controlled tumor protein 、 Biochemistry 、 Signal peptide 、 Mast cell 、 Chemotaxis 、 Biology
摘要: Histamine-releasing factor (HRF), also termed translationally controlled tumor protein (TCTP) and fortilin, is a highly conserved, multi-functional protein. This within cell plays critical role in the fundamental processes of cell-cycle progression, proliferation, survival, malignant transformation. The same protein, despite lack signal sequence, secreted through nonclassical secretory pathway. usually HRF can activate IgE-primed basophils mast cells, works as B growth chemoattractant for eosinophils. structurally well-characterized interacts with many proteins to perform its intracellular extracellular functions. review summarizes recent studies HRF/TCTP-interacting major driving force decipher
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