Chromosomal instability and cytoskeletal defects in oral cancer cells

作者: W. S. Saunders , M. Shuster , X. Huang , B. Gharaibeh , A. H. Enyenihi

DOI: 10.1073/PNAS.97.1.303

关键词: Molecular biologyDicentric chromosomeTelophaseMultipolar spindlesChromosome instabilityMitosisAnaphaseCell biologyKinetochoreMetaphaseBiology

摘要: … more genes, a change in gene expression, or a change in gene … of genetic instability in cancer cells is the variation observed … or loss of tumor suppressor genes. For example, the 11q13 …

参考文章(43)
Miyagawa, Genetic instability and cancer. International Journal of Hematology. ,vol. 67, pp. 3- 14 ,(1998) , 10.1016/S0925-5710(97)00113-8
R B Herberman, S M Gollin, J T Johnson, C Snyderman, R Deka, T L Whiteside, D S Heo, E L Barnes, S Pan, E Walker, Biology, Cytogenetics, and Sensitivity to Immunological Effector Cells of New Head and Neck Squamous Cell Carcinoma Lines Cancer Research. ,vol. 49, pp. 5167- 5175 ,(1989)
Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Genetic instabilities in human cancers Nature. ,vol. 396, pp. 643- 649 ,(1998) , 10.1038/25292
A T Correll, J H Ford, C J Schultz, Chromosome elimination in micronuclei: a common cause of hypoploidy. American Journal of Human Genetics. ,vol. 43, pp. 733- 740 ,(1988)
RR Gould, GG Borisy, The pericentriolar material in Chinese hamster ovary cells nucleates microtubule formation Journal of Cell Biology. ,vol. 73, pp. 601- 615 ,(1977) , 10.1083/JCB.73.3.601
Mary A. Dionne, Louisa Howard, Duane A. Compton, NuMA is a component of an insoluble matrix at mitotic spindle poles. Cytoskeleton. ,vol. 42, pp. 189- 203 ,(1999) , 10.1002/(SICI)1097-0169(1999)42:3<189::AID-CM3>3.0.CO;2-X
Steven E. Benner, Scott M. Lippman, Michael J. Wargovich, J. Jack Lee, Marco Velasco, Jack W. Martin, Bela B. Toth, Waun K. Hong, Micronuclei, a biomarker for chemoprevention trials: results of a randomized study in oral pre-malignancy. International Journal of Cancer. ,vol. 59, pp. 457- 459 ,(1994) , 10.1002/IJC.2910590403