Hippocampal-Dependent Inhibitory Learning and Memory Processes in the Control of Eating and Drug Taking.

摘要: As manifestations of excessive and uncontrolled intake, obesity drug addiction have generated much research aimed at identifying common neuroadaptations that could underlie both disorders. Much work has focused on changes in brain reward motivational circuitry can overexcite eating drug-taking behaviors. We suggest the regulation behaviors depends balancing excitation produced by stimuli associated with food rewards behavioral inhibition physiological "satiety" other signal when those are unavailable. Our main hypothesis is dysregulated use consequences diet- drug-induced degradations this inhibitory power. first outline a learning memory mechanism drug-intake, we describe data identifies hippocampus as substrate for mechanism. then present evidence obesitypromoting western diets (WD) impair operation process generate pathophysiologies disrupt hippocampal functioning. Next, parallel drugs abuse also same similar pathophysiologies. recent findings prior WD intake elevates self-administration, implications using (i.e., glucagon-like peptide- 1 agonists) enhance functioning to treat considered. conclude description how initiate "vicious-cycle" pathophysiology impaired hippocampal-dependent inhibition.