Concomitant sensitization to ragweed and mugwort pollen: who is who in clinical allergy?

摘要: Abstract Background In many areas of Europe, double sensitization to ragweed and mugwort is common, because the overlapping flowering periods 2 plants, it not possible diagnose primary sensitizing allergen source hence determine proper immunotherapy. Objectives To elucidate whether double-sensitized patients are cosensitized or cross-sensitized and, in latter case, define sensitizer. Methods Serum samples from 34 with late summer respiratory allergy underwent skin prick testing whole ragweed, extracts were analyzed for their reactivity recombinant Art v 1 Amb a by ImmunoCAP then 1, 6, isoforms proteomic approach. reactors, sources detected inhibition experiments. Results monosensitized contained IgE epitopes specific all isoforms. contrast, serum reactors found be primarily sensitized reacted 6 cross-reacted few Finally, reacting isoforms, part which 6. We did find patients. Conclusion This study that plays an important role cross-reactivity between frequent, bidirectional, clinically relevant area Milan.