Detection of risk factors for systemic adverse reactions to SCIT with natural depot allergen extracts: a retrospective study.

摘要: Summary Background. Some patients seem to show a particular propensity experience systemic reactions (SR) when undergoing SCIT. This study looked at their features. Methods. 423 adults submitted subcutaneous immunotherapy (SCIT) with 583 depot allergens extracts were studied. A “slow” build-up schedule was followed, and maintenance doses given monthly. No mixtures of employed; multi-sensitized treated two the same time. IgE pollen allergen components measured. Patients experiencing several SR those showing repeated large local preventing up dosing analyzed. Results. Altogether, 14% experienced least 2 SCIT further 13% reactions. All involved skin. Eight treatments stopped. reactor using beta-blockers. not associated season, use freshly prepared vials, administration allergens, or extract producer, nor preceded by Reactors younger than tolerant subjects (p < 0.05), females less frequently fully males 0.001). The multiple regression analysis showed that both ragweed grass significantly adverse Specific Amb 1 Phl p did differ statistically between reactors subjects, whereas pollen-allergic higher levels 5. Intolerance depend on number primary sensitizations hypersensitivity pan-allergens. Conclusion. Young women hypersensitive risk for during