The REPEAT study: recognizing and evaluating periodic local reactions in allergen immunotherapy and associated systemic reactions

摘要: Background Prior studies have demonstrated that large local reactions (LLRs) to subcutaneous immunotherapy do not predict systemic (SRs). However, a recent study an increase in LLRs among reactors practices using routine reaction dose adjustments. Objective To investigate the association between and SRs within practice does adjust for LLRs. Methods We performed retrospective analysis of electronic database during 12-month period at single site An LLR was defined as larger than size patient's palm measured 30 minutes. Logistic regression after controlling variable numbers injections visits patients. Results Three hundred sixty patients received total 9,679 (6,609 visits). Twenty-four (6.7% patients) experienced 38 (0.4% injections, 0.6% visits), whereas 46 (12.7% 51 (0.5% 0.77% Only 10 (2.8%) both SRs, 36 SR (78.3%) never had LLR. Among 24 patients, rate 1.3% (12/932) 2.0% (12/611) compared with 336 non-LLR whom 0.4% (39/8,747) 0.7% (39/5998) visits. Of these (41.7%) least 1 vs (10.7%). After number 2 per visit, subgroup were more likely their course (odds ratio, 4.7; 95% confidence interval, 1.9–11.7). Recurrent (n = 10) experience injection). Conclusions Although higher frequency course. In light similar previous study, this occurs irrespective whether adjustment protocol is used