The GILL study: glycerin-induced local reactions in immunotherapy.
作者： Christopher W. Calabria , Christopher A. Coop , Michael S. Tankersley
DOI: 10.1016/J.JACI.2007.08.016
关键词: Single site 、 Erythema 、 Gastroenterology 、 Local Reaction 、 Reaction rate 、 Immunotherapy 、 Allergen 、 Preservative 、 Injection site 、 Internal medicine 、 Medicine 、 Immunology
摘要: Background The mechanism of local reactions is not well defined. Glycerin, an excellent preservative used commonly in immunotherapy extracts, a recognized irritant. Objective This study was undertaken to examine whether higher glycerin concentration extracts associated with increase reaction rates during immunotherapy. Methods A retrospective analysis electronic records over 12-month period performed from single site. small defined as induration and/or erythema at the injection site smaller than or equal size patient's palm. large larger Results Over period, 360 patients received total 9678 injections. For all injections, rate 16.3% (1574/9678), 15.9% (1536/9678), and 0.4% (38/9678). aeroallergens, increased significantly increasing allergen concentrations, 7.3% (1:1000 vol/vol) 23.0% (1:1 vol/vol; P Conclusions Small local, but concentration, number, volume. Higher concentrations (even 50%) are rates.
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