The rate of systemic reactions to immunotherapy injections is the same whether or not the dose is reduced after a local reaction.

摘要: Background Even though no studies have shown that local reactions to immunotherapy injections predict subsequent systemic reactions, many protocols continue call for dose adjustments after reactions. Objective To determine whether the rate of is affected by adjustment Methods In our clinic before March 1999, if a patient had reaction an injection, was made repeat or reduce next dose. From 1999 on, such were made. At outlying clinics, protocol continued. A retrospective review conducted shots given from 1997 February 2001, recording visit resulted in reaction. Results clinic, there 3,250 shot visits (adjustment protocol) and 4,692 2001 (no protocol). The during 2 periods not different (1.11% vs 0.85%, P = .29). 1,138 protocol), than (0.88% .86). Conclusions same adjusted These are thus unnecessary, eliminating them lessens chances errors decreases number required reach therapeutic