Systemic tolerability of specific subcutaneous immunotherapy with index-of-reactivity–standardized allergen extracts administered using clustered regimens: a retrospective, observational, multicenter study

摘要: Background Subcutaneous immunotherapy is an etiological therapy for certain IgE-mediated diseases. It usually administered in 2 phases: induction and maintenance. Administration clustered schedules during the phase may be a valid alternative to reach maintenance dose early if treatment well tolerated. Objectives To compare tolerability of different subcutaneous with standardized allergen extracts identify factors associated increased risk systemic reactions (SRs). Methods Retrospective, observational, multicenter study patients allergic respiratory disease. Results Data from 1,147 were collected. Thirty-nine (3.4%) experienced 42 SRs (0.6% doses). According European Academy Allergy Clinical Immunology SR grading system, there 7 grade 0 (16.7%), 26 1 (61.9%), 8 (19.0%), 3 reaction (2.4%). There no 4 (anaphylactic shock). We observed higher who received initial than 0.3 index reactivity (IR); only occurred after administration regimen, both 0.4 IR. The remainder appeared subsequent injections, although never lower 0.35 Conclusions Clustered regimens IR-standardized are classic thanks their low incidence compared other rapid phase. ideal regimen should start at greater IR minimize SRs.