Systemic reactions to immunotherapy.

摘要: Systemic anaphylactic reactions occur in a small percentage of patients receiving allergen immunotherapy. A 1 year study was performed large health maintenance organization to determine the incidence systemic (SR) We measured number SR that occurred during 12 months period. data sheet completed for each reaction, documenting time onset, symptoms, treatment, history asthma or previous and concentration type extract. Twenty-seven thousand eight hundred six injection visits resulted 143 (0.51%). Forty-five percent (pts) with had prior SR, 50% asthma, 36% developed season. Seventy-two started within 30 minutes, although 8% appeared after 2 hours. Fifty-seven at concentrations 1,000-10,000 PNU/cc, 25% 10-100 17% when both were given same visit. Eighty-three judged be mild, nonlife threatening reactions, requiring no treatment antihistamine therapy only. Seventeen more severe, epinephrine, without other agents. are but definite risk Most some may life threatening. The majority significant both.