Local hyperthermia, radiation therapy, and chemotherapy in patients with local-regional recurrence of breast carcinoma

摘要: Abstract We retrospectively reviewed the response rate and acute long-term toxicity of combined treatment using radiation therapy, hyperthermia, chemotherapy in 29 patients with locally or regionally recurrent advanced adenocarcinoma breast who completed at least 4 6 prescribed hyperthermia treatments as part a Phase I-II trial. Thirty-nine separate fields were evaluated. Cisplatin alone cisplatin etanidazole bleomycin was delivered just prior to once weekly. Hyperthermia target minimum tumor temperature 43±C ± 0.5 for 60 min. Following 400 cGy fraction given. The size on other days 200 cGy. Twenty-two had previously been irradiated 17 not. Prior given 24 (83%) hormonal therapy 21 (72%). median follow-up time is 10 months; 16/29 (55%) have died disease. overall complete all 53%. Response not related any clinical factor, dose, microwave ultrasound technique, type chemotherapy, temperatures, but number study population small. A statistically significant association between likelihood complications total dose (previous present radiation) found. Persistent ulceration lasting greater than 1 month after completing seen 67% compared % that treated ( p = 0.015). Surgical wound repair needed 38% history irradiation versus 6% those without 0.050). found these complications. None parameters studied correlated an increased risk complication. conclude combination results high response. However, this may be more toxic alone. precise impact therapeutic index remains determined randomized trials.