The efficacy and safety of two low-dose peri-operative dexamethasone on pain and recovery following total hip arthroplasty: a randomized controlled trial

摘要: To evalute the efficacy and safety of two low-dose peri-operative dexamethasone on pain recovery following total hip arthroplasty (THA). One hundred ten patients received two-dose 10 mg IV-dexamethasone (group dexa) or IV-isotonic saline placebo). The level C-reactive protein (CRP) interleukin-6 (IL-6), at rest during mobilization, incidence post-operative nausea vomiting (PONV), intensity nausea, fatigue, consumption analgesic antiemetic rescue, range motion (ROM), length stay (post-operative LOS), wound problems complications were recorded compared. inflammation markers (CRP, IL-6) in group dexa was lower than placebo 24, 48, 72 hours post-operatively. Dynamic VAS score 24 (P = 0.002), however, there no significant effect rest. In dexa, had a PONV (P = 0.003), as well (P = 0.044). fatigue (P < 0.001) relieved rescues reduced. Furthermore, better maximum flexion abduction (P = 0.017), with shorter LOS (P = 0.006). There is difference between groups problems. No surgical site infection gastrointestinal haemorrhage detected both groups. administration can effectively reduce CRP IL-6, provide additional control, ameliorate enhance mobility, shorten THA, without increasing risk hemorrhage. Level evidence: I