Oral vs Intravenous vs Topical Tranexamic Acid in Primary Hip Arthroplasty: A Prospective, Randomized, Double-Blind, Controlled Study.

摘要: Abstract Background Tranexamic acid (TXA) has demonstrated efficacy in reducing blood loss, reduction hemoglobin, and transfusion requirements primary total hip arthroplasty (THA). The optimal mode of TXA administration for patients undergoing THA is unclear. purpose this randomized controlled trial to determine whether oral was superior intravenous or topical routes these patients. Methods In double-blinded, placebo-controlled trial, were (2 g orally 2 hours preoperatively), (20 mg/kg bolus 5 minutes before the incision), applied topically) groups. outcome hemoglobin. Secondary outcomes included rate, cost (Chinese yuan (¥); 2017, ¥1 = $0.147), adverse events. Results One hundred eighty into 3 Demographic characteristics similar among mean hemoglobin oral, intravenous, groups (3.48 ± 1.32, 3.58 1.07, 3.66 1.26 g/dL, respectively). Similarly, loss did not differ significantly group incurred lowest (¥480) compared with that (¥3329.28) (¥3540) (P = .01). None sustained a deep venous thrombosis, pulmonary embolism, an infection. Conclusion blood-sparing comparable forms. Oral recommended because its cost-benefit superiority ease administration.