Fused bicyclic pyrimidine derivatives and uses thereof

摘要: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, compositions thereof. Also provided are methods kits involving the inventive or for treating preventing proliferative diseases (e.g., cancers lung cancer, breast leukemia, lymphoma, melanoma, multiple myeloma, Ewing's sarcoma, osteosarcoma, brain neuroblastoma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory autoimmune diseases) in a subject. Treatment subject with disease using compound composition may inhibit aberrant activity kinase (e.g. protein cyclin-dependent (CDK) CDK7, CDK12, CDK13) lipid such as phosphatidylinositol- 5 -phosphate 4- (PIP4K) ΡΙ5Ρ4Κα, ΡΙ5Ρ4Κβ, ΡΙ5Ρ4Κγ))