Flower-like calcium phosphoserine complex as biomimetic mineral with high bioactivity

摘要: Abstract Biomineralization is a set of processes whereby living organisms generate hierarchically structured organic–inorganic materials. Studies on biomineralization not only elucidate the natural process biomineral formation but also contribute to development functional biomaterials. However, function small molecules in has been clarified. In this study, phosphoserine (PS) was used as phosphorus source prepare biomimetic minerals, and new flower-like complex calcium PS (CaPS) obtained. The CaPS samples were self-assembled plate-like crystals first 10 min. Then, over next 5 h reaction, broken down into fine granular nanoparticles. chemical thermal properties characterized, results indicated that or had similar structure Ca(C3H6NO6P)·H2O. X-ray absorption near edge (XANES) extended spectra (EXAFS) obtained, which clearly revealed 6-fold-coordinated Ca-O bonds with lengths 2.319 (±0.0147) A, 2.358 2.435 A. Furthermore, CCK-8 assay high biocompatibility CaPS. When co-cultured mouse preosteoblast cells (MC3T3-E1), exhibited good bioactivity promote osteoblast differentiation cells. Owing its excellent biological properties, as-prepared promising for various biomedical applications.