Influence of age at inoculation on avian oncornavirus-induced brain tumor incidence, tumor morphology, and postinoculation survival in F344 rats.

摘要: Summary Intracranial neoplasms were induced by intracerebral inoculation of a standardized, cell-free inoculum the Bratislava-77 strain avian sarcoma virus in F344 rats at 1, 9, 97 to 99, and 528 days age. Deaths from diseases that occur spontaneously aged complicated assessment tumor incidence inoculated days; 20 30 this age developed brain tumors. All 1 day (47 rats), 9 (37 99 (41 rats) The animals developing tumors was 100% these three groups, but multiple declined with increasing inoculation. mean variance postinoculation survival increased 83.8 ± 21.5 for 284.6 151.5 Poorly differentiated astrocytomas mixed morphology common among as neonates. Solitary, pilocytic most adults.