摘要: Since the end of 'no-new-neuron' theory, emerging evidence from multiple studies has supported existence stem cells in neurogenic areas adult brain. Along with this discovery, neural became candidate being at origin brain tumors. In fact, it been demonstrated that molecular mechanisms controlling self-renewal and differentiation are shared between tumor corruption genes implicated these pathways can direct growth. regard, future anticancer approaches could be inspired by uncovering such redundancies setting up treatments leading to exhaustion cancer cell pool. However, deleterious effects on (normal) should minimized. Such therapeutic models underline importance study cellular fate decisions oncogenic derivation cells. review, we discuss putative origins their possible implications therapies.
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