Serial interferon‐γ release assay in children with latent tuberculosis infection and children with tuberculosis
作者： Nataųa Nenadić , Branka Kristić Kirin , Ivka Zoričić Letoja , Davor Plavec , Renata Zrinski Topić
DOI: 10.1002/PPUL.21555
关键词: Interferon gamma release assay 、 Medicine 、 Long period 、 Internal medicine 、 Interferon γ 、 Immunology 、 Signs and symptoms 、 Active tuberculosis 、 Significant difference 、 Latent tuberculosis 、 Tuberculosis
摘要: Interferon-γ (IFN-γ) release assay (IGRA) is used for diagnosis of latent tuberculosis infection (LTBI), and serial testing active (TB). The aim this study was to evaluate the results IGRA treatment monitoring children with LTBI TB. performed in BCG vaccinated before six months after beginning treatment. A total 59 aged 4-18 years were investigated due exposure participants divided into two groups: Group 1, (N = 41), 2, TB (N = 18). (QuantiFERON-TB Gold In-Tube) twice, i.e., at end prophylaxis therapy. There no significant difference IFN-γ concentrations between 1 2 subjects either or Difference pre-treatment post-treatment compared not statistically significant. During follow-up, did develop In addition, TB, signs symptoms improved anti-TB This showed that differ may remain positive over a long period time. It seems useful Pediatr Pulmonol.
irb.hr
sci-hub.se 参考文章(28)
P. C. Hopewell, A. Kalantri, P. C. Hill, D. Menzies, A. A. Zwerling, M. Pai, M. V. R. Reddy, K. Goswami, S. Dogra, D. Gajalakshmi, R. Joshi, T-cell assay conversions and reversions among household contacts of tuberculosis patients in rural India International Journal of Tuberculosis and Lung Disease. ,vol. 13, pp. 84- 92 ,(2009)
E. de la Morena, J. Martinez, G. del Rio, J. Latour, P. Cabrera, 2,3-Diphosphoglycerate in arterial and venous blood in normal individuals and in those with respiratory insufficiency Biochemical Medicine. ,vol. 20, pp. 15- 22 ,(1978) , 10.1016/0006-2944(78)90045-5
M. P. Nicol, D. Pienaar, K. Wood, B. Eley, R. J. Wilkinson, H. Henderson, L. Smith, D. Beatty, Enzyme-Linked Immunospot Assay Responses to Early Secretory Antigenic Target 6, Culture Filtrate Protein 10, and Purified Protein Derivative among Children with Tuberculosis: Implications for Diagnosis and Monitoring of Therapy Clinical Infectious Diseases. ,vol. 40, pp. 1301- 1308 ,(2005) , 10.1086/429245
Madhukar Pai, Richard O'Brien, Serial Testing for Tuberculosis: Can We Make Sense of T Cell Assay Conversions and Reversions? PLoS Medicine. ,vol. 4, pp. e208- ,(2007) , 10.1371/JOURNAL.PMED.0040208
Marius Marusteri, Vladimir Bacarea, Comparing groups for statistical differences: how to choose the right statistical test? Biochemia Medica. ,vol. 20, pp. 15- 32 ,(2010) , 10.11613/BM.2010.004
Madhukar Pai, Alice Zwerling, Dick Menzies, Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Annals of Internal Medicine. ,vol. 149, pp. 177- 184 ,(2008) , 10.7326/0003-4819-149-3-200808050-00241
Dick Menzies, Madhukar Pai, George Comstock, Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Annals of Internal Medicine. ,vol. 146, pp. 340- 354 ,(2007) , 10.7326/0003-4819-146-5-200703060-00006
Young Ae Kang, Hye Won Lee, Ho Il Yoon, BeLong Cho, Sung Koo Han, Young-Soo Shim, Jae-Joon Yim, Discrepancy Between the Tuberculin Skin Test and the Whole-Blood Interferon γ Assay for the Diagnosis of Latent Tuberculosis Infection in an Intermediate Tuberculosis-Burden Country JAMA. ,vol. 293, pp. 2756- 2761 ,(2005) , 10.1001/JAMA.293.22.2756
Deborah A Lewinsohn, Mark N Lobato, John A Jereb, Interferon-γ release assays: new diagnostic tests for Mycobacterium tuberculosis infection, and their use in children Current Opinion in Pediatrics. ,vol. 22, pp. 71- 76 ,(2010) , 10.1097/MOP.0B013E3283350301
Madhukar Pai, Spectrum of latent tuberculosis — existing tests cannot resolve the underlying phenotypes Nature Reviews Microbiology. ,vol. 8, pp. 242- 242 ,(2010) , 10.1038/NRMICRO2236-C1