Skull base chondrosarcoma. An interdisciplinary challenge

作者: P. U. Lohnstein , J. Schipper , M. Tatagiba , N.-C. Gellrich , A. Berlis

DOI: 10.1007/S00106-005-1324-0

关键词: MedicineAdvanced stageDifferential diagnosisComplete resectionClose relationshipChondrosarcomaSkullSurgeryResectionRadiation therapy

摘要: BACKGROUND Chondrosarcoma is a rare differential diagnosis of malignant tumours the skull base. The prognosis was rated as unfavourable in articles for many years. It has, however, improved considerably recent objective this study to evaluate and current, new optimised treatment strategies. PATIENTS AND METHODS We retrospectively analysed case histories course four patients whom we treated chondrosarcoma base over past 5 years at Freiburg Skull Base Centre. RESULTS Because initially mild symptoms, first came examination an advanced stage tumour. All underwent surgery, whereby R0-resection barely or only questionably present. Three radiation therapy postoperatively. are currently tumour free. CONCLUSIONS Surgical with curative intent basically choice. Due usually large size its close relationship relevant structures, complete resection is, not always possible despite advances surgical procedures. Taking possibility modern adjuvant radiotherapeutic procedures into account, incomplete, function-preserving preferred radical mutilating resection.

参考文章(38)
K. Donath, G. Seifert, Kraniale und zervikale Chordome Mund-, Kiefer- Und Gesichtschirurgie. ,vol. 2, pp. 153- 159 ,(1998) , 10.1007/S100060050051
Eiji Tachibana, Kiyoshi Saito, Masakatsu Takahashi, Keizo Fukuta, Jun Yoshida, Surgical treatment of a massive chondrosarcoma in the skull base associated with Maffucci’s syndrome: a case report Surgical Neurology. ,vol. 54, pp. 165- 170 ,(2000) , 10.1016/S0090-3019(00)00252-4
S. R. Stapleton, P. R. Wilkins, D. J. Archer, D. Uttley, Chondrosarcoma of the skull base: a series of eight cases. Neurosurgery. ,vol. 32, pp. 348- 356 ,(1993) , 10.1227/00006123-199303000-00003
C N Sen, L N Sekhar, V L Schramm, I P Janecka, Chordoma and chondrosarcoma of the cranial base: an 8-year experience. Neurosurgery. ,vol. 25, pp. 931- 941 ,(1989) , 10.1097/00006123-198912000-00013
Brian Neff, Robert Thayer Sataloff, Leslie Storey, Mary Hawkshaw, Joseph R. Spiegel, Chondrosarcoma of the skull base. Laryngoscope. ,vol. 112, pp. 134- 139 ,(2002) , 10.1097/00005537-200201000-00023
Andrew R. Harwood, J. Ivan Krajbich, Victor L. Fornasier, Radiotherapy of chondrosarcoma of bone Cancer. ,vol. 45, pp. 2769- 2777 ,(1980) , 10.1002/1097-0142(19800601)45:11<2769::AID-CNCR2820451111>3.0.CO;2-X
F. Cianfriglia, A. Pompili, E. Occhipinti, Intracranial malignant cartilaginous tumours. Report of two cases and review of literature. Acta Neurochirurgica. ,vol. 45, pp. 163- 175 ,(1978) , 10.1007/BF01774391
Harald Eufinger, Michael Wehmöller, Microsurgical Tissue Transfer and Individual Computer-aided Designed and Manufactured Prefabricated Titanium Implants for Complex Craniofacial Reconstruction Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. ,vol. 36, pp. 326- 331 ,(2002) , 10.1080/028443102321096311
D. P. C. Lau, S. B. Wharton, N. M. Antoun, I. D. Bottrill, D. A. Moffat, Chondrosarcoma of the petrous apex. Dilemmas in diagnosis and treatment Journal of Laryngology and Otology. ,vol. 111, pp. 368- 371 ,(1997) , 10.1017/S002221510013734X