Usefulness of analytical CEA doubling time and half-life time for overlooked synchronous metastases in colorectal carcinoma.

摘要: Background: Measurement of carcinoembryonic antigen (CEA) has been widely applied to detect recurrence, especially colorectal carcinoma. The validity however, is still controversial. We investigated serial changes in CEA values calculate whether the doubling time and half-life could predict metastatic progression or prognosis Methods: Pre- post-operative serum contents were determined 22 cases cancer with without metastasis. by enzyme immunoassay (EIA). Patients assigned depending upon survival (within vs more than 18 months after primary resection) for assessment time. From gradient semi-logarithmic graph, preoperative was calculated postoperative estimated according diagnosis metastases within 2 years resection [metastasis (+) (–)]. Results: In spite effect curative re-operation lesions adjuvant chemotherapy, groups showed a relation (p = 0.045, Student’s t-test) when patients divided into >18 ≤18 overlooked statistically longer those (mean ± SD 8.01 2.07 4.33 1.11, respectively, p < 0.01, onefactor ANOVA test). Clearance (k) significant difference between 0.001, t-test). Conclusion: appeared be less independent prognostic factor, whereas prolongation might potentially suggest existence synchronous from