Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner

摘要: To examine the dose–response effects of acute glutamine supplementation on markers gastrointestinal (GI) permeability, damage and, secondary, subjective symptoms GI discomfort in response to running heat. Ten recreationally active males completed a total four exercise trials; placebo trial and three trials at 0.25, 0.5 0.9 g kg−1 fat-free mass (FFM) consumed 2 h before exercise. Each consisted 60-min treadmill run 70% $$\dot {V}{{\text{O}}_{{\text{2max}}}}$$ an environmental chamber set 30 °C. permeability was measured using ratio lactulose rhamnose (L:R) serum. Plasma intestinal fatty acid binding protein (I-FABP) concentrations were determined pre post Subjective assessed 45 min 24 h post-exercise. Relative placebo, L:R likely lower following 0.25 g kg−1 (mean difference: − 0.023; ± 0.021) (− 0.019; ± 0.019) very g kg− 1 (− 0.034; ± 0.024). typically low there no effect supplementation. Acute oral consumption attenuates relative even doses g kg−1, although larger may be more effective. It remains unclear if this will lead reductions symptoms. Athletes competing heat may, therefore, benefit from prior order maintain integrity.