Transforming growth factor-beta. Multiple actions and potential clinical applications
作者： M. B. Sporn
关键词: Transforming growth factor, beta 3 、 Transforming growth factor 、 Medicine 、 Endocrinology 、 Cell biology 、 Transforming growth factor beta 、 Internal medicine 、 Cell physiology 、 Receptor 、 Platelet 、 Cellular differentiation 、 Wound healing
摘要: THE CURRENT excitement in research on transforming growth factor—β (TGF-β) comes from its multiple actions almost every type of cell and potential for therapeutic use common clinical conditions which there are no adequate pharmacologic agents. Although TGF-β was identified originally an assay that measured ability to enhance the fibroblasts soft agar ("transformation"), true importance is as a mediator normal cellular physiology, particular during formation tissues (as embryogenesis) tissue response injury inflammation repair). Almost all cells have been shown make one molecular forms, al— most receptors TGF-β. Transforming factor—β1 highly stable peptide consists two identical chains, each containing 112 amino acids. It first isolated characterized human platelets placentas well
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