The role of H2-receptor antagonists in the prevention of NSAID-induced gastrointestinal damage.
作者： D. RACHMILEWITZ
DOI: 10.1111/J.1365-2036.1988.TB00766.X
关键词: Histamine H2 receptor 、 Duodenum 、 Pharmacology 、 Naproxen 、 Stomach 、 Anesthesia 、 Medicine 、 Gastric acid 、 Aspirin 、 Cimetidine 、 Gastric mucosa
摘要: SUMMARY Non-steroidal anti-inflammatory drugs (NSAIDs) induce gastric and duodenal damage in animals humans. The possible protection afforded by cimetidine against acute short-term NSAID-induced mucosal was evaluated five studies. Cimetidine 200 mg once daily 400 found to protect the mucosa induced a single dose of aspirin 1300 mg; this be independent acid secretion. q.d.s. stomach duodenum 14 days’treatment with 650 Duodenal during 7-day treatment period naproxen 500 b.d. prevented b.d.; also provided significant I week therapy indomethacin 50 t.d.s. There is no correlation between upper gastrointestinal symptoms, or prostanoids, presence absence damage. therefore effective prevention NSAIDs.
sci-hub.se 参考文章(29)
Magne Osnes, Stig Larsen, Willy Eidsaunet, Erling Thom, Effect of diclofenac and naproxen on gastroduodenal mucosa Clinical Pharmacology & Therapeutics. ,vol. 26, pp. 399- 405 ,(1979) , 10.1002/CPT1979263399
Hoftiezer Jw, O'Laughlin Jc, Ivey Kj, Effect of aspirin on the human stomach in normals: endoscopic comparison of damage produced one hour, 24 hours, and 2 weeks after administration. Scandinavian Journal of Gastroenterology. ,vol. 67, pp. 211- 214 ,(1981)
Yoshiteru Azuumi, Kazuhiko Ishihara, Susumu Ohara, Haruya Okabe, Kyoko Hotta, Efficacy of anti-ulcer drugs on the recovery of gastric mucosal glycoproteins with aspirin-induced gastric damage in rat Gastroenterologia Japonica. ,vol. 16, pp. 331- 334 ,(1981) , 10.1007/BF02774464
Daniel Rachmilewitz, Moshe Ligumsky, Alexander Fich, Eran Goldin, Abraham Eliakim, Fanny Karmeli, Role of endogenous gastric prostanoids in the pathogenesis and therapy of duodenal ulcer Gastroenterology. ,vol. 90, pp. 963- 969 ,(1986) , 10.1016/0016-5085(86)90874-7
Moshe Ligumsky, Elizabeth M. Golanska, Duane G. Hansen, Gordon L. Kauffman, Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat Gastroenterology. ,vol. 84, pp. 756- 761 ,(1983) , 10.1016/0016-5085(83)90143-9
Anthony I. Stern, Daniel L. Hogan, Jon I. Isenberg, A new method for quantitation of ion fluxes across in vivo human gastric mucosa: Effect of aspirin, acetaminophen, ethanol, and hyperosmolar solutions Gastroenterology. ,vol. 86, pp. 60- 70 ,(1984) , 10.1016/0016-5085(84)90590-0
Richard W. Welch, H.Leonard Bentch, Steven C. Harris, Reduction of aspirin-induced gastrointestinal bleeding with cimetidine. Gastroenterology. ,vol. 74, pp. 459- 463 ,(1978) , 10.1016/0016-5085(78)90781-3
Allan R. Cooke, The role of acid in the pathogenesis of aspirin-induced gastrointestinal erosions and hemorrhage The American Journal of Digestive Diseases. ,vol. 18, pp. 225- 237 ,(1973) , 10.1007/BF01071977
A. R. Cooke, Gastric Damage by Drugs and the Role of the Mucosal Barrier Australian and New Zealand Journal of Medicine. ,vol. 6, pp. 26- 29 ,(1976) , 10.1111/J.1445-5994.1976.TB03670.X
I Caruso, G B. Porro, Gastroscopic evaluation of anti-inflammatory agents BMJ. ,vol. 280, pp. 75- 78 ,(1980) , 10.1136/BMJ.280.6207.75