Efficacy of anti-ulcer drugs on the recovery of gastric mucosal glycoproteins with aspirin-induced gastric damage in rat

摘要: The efficacy of two anti-ulcer drugs, Cimetidine and Cetraxate, on the mucus glycoproteins gastric mucosa in aspirin-induced damage was studied rats. Simultaneous or previous oral administration Cetraxate with aspirin reduced diminution which occurred by administration. recovery content glycoprotein drug dosed rats within 3 h after dosing nearly 90% control at 5 all cases. Single produced an increase greater than that untreated control. Although a macroscopical method for measurement applied to this work, neither erosions nor linear ulcers were observed cases except single aspirin. biochemical used should be able assess drugs mucosal lesion cannot expressed as ulcer index.