作者: Michael D. Bowen , Slavica Mijatovic-Rustempasic , Mathew D. Esona , Elizabeth N. Teel , Rashi Gautam
关键词: Genotype 、 Rotavirus Infections 、 Genotyping 、 Rotavirus 、 Disease control 、 Genotype determination 、 Virology 、 Group A rotaviruses 、 Internal medicine 、 Medicine
摘要: Background Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at hospitals and emergency departments 3-7 geographically diverse sites in the United States since 2006. Methods Over 6 consecutive years, from 2008 to 2013, 1523 samples NVSN that were tested positive by Rotaclone enzyme immunoassay submitted Centers Disease Control Prevention genotyping. Results In 2009, 2010, 2011 seasons, genotype G3P[8] was predominant throughout network, with 46%-84% prevalence. 2012 season, G12P[8] replaced as most common genotype, 70% prevalence, this trend persisted 2013 (68.0% prevalence). (RotaTeq; Rotarix) strains detected 0.6%-3.4% genotyped each season. Uncommon unusual (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], G9P[4]) sporadically over study period. Year, site, race found be predictors genotype. Conclusions Continued is needed monitor genotypes detect potential changes vaccine licensure.