Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008-2013.

作者: Michael D. Bowen , Slavica Mijatovic-Rustempasic , Mathew D. Esona , Elizabeth N. Teel , Rashi Gautam

DOI: 10.1093/INFDIS/JIW233

关键词: GenotypeRotavirus InfectionsGenotypingRotavirusDisease controlGenotype determinationVirologyGroup A rotavirusesInternal medicineMedicine

摘要: Background Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at hospitals and emergency departments 3-7 geographically diverse sites in the United States since 2006. Methods Over 6 consecutive years, from 2008 to 2013, 1523 samples NVSN that were tested positive by Rotaclone enzyme immunoassay submitted Centers Disease Control Prevention genotyping. Results In 2009, 2010, 2011 seasons, genotype G3P[8] was predominant throughout network, with 46%-84% prevalence. 2012 season, G12P[8] replaced as most common genotype, 70% prevalence, this trend persisted 2013 (68.0% prevalence). (RotaTeq; Rotarix) strains detected 0.6%-3.4% genotyped each season. Uncommon unusual (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], G9P[4]) sporadically over study period. Year, site, race found be predictors genotype. Conclusions Continued is needed monitor genotypes detect potential changes vaccine licensure.

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