Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood-brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats.
作者： Hiroshi Karibe , Gregory J. Zarow , Steven H. Graham , Philip R. Weinstein
关键词: Central nervous system disease 、 Anesthesia 、 Hypothermia 、 Ischemia 、 Blood–brain barrier 、 Medicine 、 Isoflurane 、 Extravasation 、 Evans Blue 、 Perfusion
摘要: Mild to moderate hypothermia (30–33°C) reduces brain injury after brief (<2-h) periods of focal ischemia, but its effectiveness in prolonged temporary ischemia is not fully understood. Thirty-two Sprague–Dawley rats anesthetized with 1.5% isoflurane underwent 3 h middle cerebral artery occlusion under hypothermic (33°C) or normothermic (37°C) conditions followed by 21 reperfusion (n = 8/group). Laser–Doppler estimates cortical blood flow showed that intraischemic reduced both postischemic hyperperfusion (p ≤ 0.01) and delayed hypoperfusion 0.01). Hypothermia the extent blood-brain barrier (BBB) disruption as estimated from extravasation Evans blue dye at 6 onset also volume edema neuronal damage Nissl-stained slides 24 ischemia. These results demonstrate mil...
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