Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases
作者： Elsa Germain , Mohammad Roghanian , Kenn Gerdes , Etienne Maisonneuve
关键词: Stringent response 、 Multidrug tolerance 、 Translation (biology) 、 Biochemistry 、 Cell biology 、 Kinase 、 Escherichia coli 、 Effector 、 Messenger RNA 、 Guanosine 、 Biology
摘要: … )ppGpp induced slow growth, drug tolerance, and persistence. We further revealed that (p)ppGpp … nongrowing state due to a high level of (p)ppGpp were antibiotic-tolerant if they carried …
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