Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: a secondary analysis of a randomised trial

摘要: Psychological stress is associated with gastrointestinal (GI) distress. This secondary analysis from a randomised, double-blind, placebo-controlled study examined whether three different probiotics could normalise self-reported stress-associated GI discomfort and reduce overall stress. Undergraduate students (n=581) received Lactobacillus helveticus R0052, Bifidobacterium longum ssp. infantis R0033, bifidum R0071, or placebo. Participants 2 outcomes for 6-week period, which included final academic exams: daily level of (0=no to 10=extremely stressed) weekly diarrhoea-related symptoms (DS, 1=no 7=severe discomfort) using the Symptom Rating Scale. Self-reported was positively related DS (P=0.0068). Mean scores were lower B. versus placebo at week average body mass index (BMI). 5 0 1 R0033 6 0. higher when antibiotics used in prior (P=0.0092). not without antibiotic use probiotics. Only had an effect on (P=0.0086). The score also dependent hours sleep per day where it decreased by 0.13 each additional hour sleep. During stressful R0071 decreases scores. trial registered clinicaltrials.gov as NCT01709825.