Strand-specific Mismatch Repair in Mammalian Cells*

摘要: Mistakes occurring during DNA transactions necessarily produce mismatched base pairs. biosynthetic errors that escape the polymerase editing function yield mispaired bases, but mismatches also populate a recombination heteroduplex produced by strand transfer between related sequences have diverged at nucleotide level. Study of microbial systems has demonstrated importance mismatch correction in reversal such and consequent stabilization genome (1‐ 4). 1 Interest this process increased dramatically over past few years with demonstration repair plays an equally important role mutation avoidance mammalian cells finding inactivation system inherited or somatic predisposes to tumor development renders them resistant cytotoxic effects certain DNA-damaging agents. This minireview will emphasize molecular features strand-specific pathway. Work other be alluded only as necessary for clarity those instances where compelling supporting data is available.