The routine use of C-reactive protein in forensic investigations.

摘要: In clinical medicine, C-reactive protein (CRP) is extensively used as a general marker for immune system activation, and post-mortem applicability has been established [M.Q. Fujita, B.L. Zhu, K. Ishida, L. Quan, S. Oritani, H. Maeda, Serum levels in postmortem blood-an analysis with special reference to the cause of death survival time, Forensic Sci. Int. 130 (2002) 160-166; Uhlin-Hansen, (CRP), comparison pre- blood levels, 124 (2001) 32-35]. We have analysed routine use CRP non-selected cases. Scarcity available common problem forensic investigation, response this we developed method using liver source. 50 consecutive autopsy cases, evaluated method, validated results discussed their interpretation. three cases was not possible. For each remaining (n=47) whole blood, serum and/or samples. 57% (n=25) had > 10 mg/L. were higher than or liver. samples stable more one month after death, making storage later Liver peaked at week, but putrefaction obvious. independent interval. The source yet described literature. Our correlate well plasma results, good alternative when available. conclude that measurements are easy, viable inexpensive setting, number elevation high material. doubt, marked an indicator natural mode trauma, it indicates vital reaction. It can be pre-autopsy screening, leading extensive search diseases easily diagnosed, such sepsis ketoacidosis.