The Non-Specific Enhancement of Allergy.

摘要: PVG rats given injections of 1 microgram ovalbumin (OA) together with 10 mg Silica gel failed to provide serosal mast cells or lung tissue the capacity release histamine on in vitro challenge antigen. However, if such animals were injected i.p. 100 alum (without any further antigen addition) 3-9 weeks after primary injection, their and showed a clear-cut respond vitro, when examined week injection. Injection only 15 did not induce response capacity. The fading reactivity induced by an injection could be prevented repeated adjuvant alone. Pretreatment cyclophosphamide (33 mg/kg) 2 days before affect booster 3 later. S.c. also precipitated primed gel. anaphylactic injection(s) was generally accompanied increased levels OA-IgE especially OA-IgG2a antibody; however, correlation between either cell serum IgG2a antibody titer demonstrated. These data show that animals, which do express allergic capacity, can injecting alone, even several