Combination of epithelial-mesenchymal transition and cancer stem cell–like phenotypes has independent prognostic value in gastric cancer
作者： Han Suk Ryu , Do Joong Park , Hyung Ho Kim , Woo Ho Kim , Hye Seung Lee
DOI: 10.1016/J.HUMPATH.2011.07.003
关键词: Pathology 、 CD44 、 Epithelial–mesenchymal transition 、 Biology 、 Cancer cell 、 Cancer 、 Vimentin 、 Cancer stem cell 、 Stomach cancer 、 Lymph node
摘要: Summary Epithelial-mesenchymal transition–related proteins have been suggested to interact with each other in various cancers and be associated the aggressive behavior of cancer. To demonstrate clinical significance epithelial-mesenchymal transition stem cell–like phenotypes gastric cancer, we performed immunohistochemistry for 5 proteins, including Snail-1, ZEB-1, E-cadherin, vimentin, β -catenin, cancer cell marker CD44 276 consecutive primary 54 matched lymph node metastases. Loss E-cadherin expression aberrant vimentin were significantly clinicopathologic features. The was closely related known maker, CD44, protein ( P value using Kaplan-Meier method = .029). However, acquired mesenchymal phenotype cells at site restored an epithelial A combination is important predictor biologic has independent prognostic predicting outcomes
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