Lipoprotein profile, lipoprotein-associated phospholipase A2 and cardiovascular risk in hemodialysis patients.

摘要: Cardiovascular disease is the leading cause of morbidity and mortality in hemodialysis patients; increased risk cardiovascular due to accelerated atherosclerosis, inflammation impaired lipoprotein metabolism. We aimed evaluate lipoprotein-associated phospholipase A2 (Lp-PLA2) some pro-inflammatory aspects profile dialyzed patients order relationship with atherosclerosis vascular accidents. In 102 dialysis 40 non-uremic controls, we investigated plasma profile, high sensitivity C-reactive protein (CRP), ceruloplasmin serum amyloid A (SAA), followed for 1 year analyze acute events. Total cholesterol, low-density high-density levels were significantly lower uremic than whereas CRP, SAA, ceruloplasmin, Lp-PLA2 their ratio apolipoprotein A1 higher. Patients >194 nmol/min/ml had more events values. Our results show that subjects: (1) lipoproteins a atherogenic phenotype general population; (2) are less anti-inflammatory; (3) could potentially be used risk.